First total synthesis of the marine natural products clavulolactones II and III.
نویسندگان
چکیده
The first total synthesis of the marine prostanoids clavulolactones II and III is presented from an easily accessible chiral, non-racemic cyclopentenone intermediate. Key steps involve selective TBDMS deprotection, selective reduction of the β-side chain and aldol condensation. Clavulolactones II and III were successfully prepared from (S)-4-((tert-butyldimethylsilyl)oxy) cyclopent-2-en-1-one over nine steps, in overall yields of 21 and 7% respectively.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 13 شماره
صفحات -
تاریخ انتشار 2015